Traditional and newly developed testing methods were used for extensive
application-related characterization of transdermal therapeutic systems (TTS) and
pressure sensitive adhesives (PSA). Large amplitude oscillatory shear tests of
PSAs were correlated to the material behavior during the patient’s motion and
showed that all PSAs were located close to the gel point. Furthermore, an
increasing strain amplitude results in stretching and yielding of the PSA´s microstructure
causing a consolidation of the network and a release with increasing
strain amplitude. RheoTack approach was developed to allow for an advanced
tack characterization of TTS with visual inspection. The results showed a clear
resin content and rod geometry dependent behavior, and displays the PSA´s
viscoelasticity resulting in either high tack and long stretched fibrils or nonadhesion
and brittle behavior. Moreover, diffusion of water / sweat during TTS´s
application might influence its performance. Therefore, a dielectric analysis based
evaluation method displayed occurring water diffusion into the PSA from which
the diffusion coefficient can be determined, and showed clear material and resin
content dependent behavior. All methods allow for an advanced product-oriented
material testing that can be utilized within further TTS development.
| ISBN: | 978-80-7678-230-3 |
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| EAN: | 9788076782303 |
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| Počet stran |
58 stran |
| Datum vydání |
14. 03. 2024 |
| Pořadí vydání |
První |
| Jazyk |
anglický |
| Vazba |
e-kniha - pdf |
| Autor: |
Michael Meurer |
| Nakladatelství |
Univerzita Tomáše Bati ve Zlíně |
| Tématická skupina |
999 - nezařazeno |
| Neprodejná publikace. Publikaci je možné poptávat zde: Volně dostupné na http://hdl.handle.net/10563/54629 |
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