Preparation of (bio)polymer matrices for substance transfer and study of their release

The thesis focuses on the study of hydrogel films prepared from the oxidized polysaccharide crosslinkers and polyvinyl alcohol (PVA) aimed at biomedical applications, particularly drug delivery. Initially, the role of the matrix (PVA) characteristics was studied in hydrogels crosslinked by 2,3-dialdehyde cellulose (DAC) and designed for the transdermal delivery of biologically active compounds. Hydrogel structure, properties, and drug release kinetics were investigated. Optimization was achieved by varying the amounts of DAC crosslinker and weight average molecular weight (Mw) of PVA. The best results were obtained for hydrogel films using 0.25% wt. DAC and PVA with Mw=130 kDa which had high porosity, drug loading capacity, mechanical properties, and skin adhesion among all tested samples. Next, different types of oxidized dialdehyde polysaccharide crosslinkers (DAP) based on cellulose, dextran, dextrin, and hyaluronic acid were compared on the selected PVA matrix, from which PVA/DAPs hydrogel films were created. The goal was to formulate a structure/function relationship and to select the best crosslinkers for a given application. The properties of PVA/DAP hydrogels were compared based on the density of -CHO groups, the structure of the crosslinkers, the molecular weight, and the size of the crosslinker nano-assemblies formed spontaneously in their solutions. All prepared hydrogel films with different amounts of DAC and Mw PVA crosslinker (PVA /DAC) and PVA/DAPs films were analyzed based on mechanical, viscoelastic properties, porosity, swelling, water content, network parameters, and cytotoxicity. Crosslinkers based on linear polysaccharides (cellulose, hyaluronate) performed more reliably, while the presence of branching could be both beneficial (dextran) and detrimental (dextrin) at lower crosslinker concentrations.

ISBN:	978-80-7678-227-3
EAN:	9788076782273
Počet stran	52 stran
Datum vydání	14. 03. 2024
Pořadí vydání	První
Jazyk	anglický
Vazba	e-kniha - pdf
Autor:	Monika Muchová
Nakladatelství	Univerzita Tomáše Bati ve Zlíně
Tématická skupina	999 - nezařazeno
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